Acetaldehyde – The major metabolic product of ethanol, which is generated by ethanol dehydrogenase and subsequently metabolised to acetate by aldehyde dehydrogenase. It is responsible for alcohol’s toxic effects.

It is postulated that the liver injury induced by ethanol is due to tissue responses to acetaldehyde, including acetaldehyde-induced fibrogenesis, acetaldehyde-induced lipid peroxidation enzyme inhibition, and formation of antibodies against acetaldehyde adduct proteins—e.g., serum albumin, hemoglobin, and cytokskeletal proteins, including tubulin.


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